NIH Clinical Center Releases Dataset of 32,000 CT Images

The National Institutes of Health’s Clinical Center has made a large-scale dataset of CT images publicly available to help the scientific community improve detection accuracy of lesions. While most publicly available medical image datasets have less than a thousand lesions, this dataset, named DeepLesion, has over 32,000 annotated lesions identified on CT images.… Read full story

NIH and Prostate Cancer Foundation Launch Large Study on Aggressive Prostate Cancer in African-American Men

The largest coordinated research effort to study biological and non-biological factors associated with aggressive prostate cancer in African-American men has begun. The $26.5 million study is called RESPOND, or Research on Prostate Cancer in Men of African Ancestry: Defining the Roles of Genetics, Tumor Markers, and Social Stress.… Read full story

Broadly Acting Antibodies Found in Plasma of Ebola Survivors

What

Recent Ebola virus disease (EVD) outbreaks, including the 2013-2016 epidemic that ravaged West Africa and the 2018 outbreak in the Democratic Republic of the Congo, highlight the need for licensed treatments for this often-deadly disease. ZMapp, an experimental therapy comprising three monoclonal antibodies, has shown promise in a clinical trial, but it targets only one of the five known species of Ebola virus.… Read full story

Fruit Fly Mating Driven by a Tweak in Specific Brain Circuit

NIH-funded study suggests that slight changes in a brain’s wiring can greatly change behavior.

According to a new National Institutes of Health-funded study, it is not destiny that brings two fruit flies together, but an evolutionary matchmaker of sorts that made tiny adjustments to their brains’ mating circuits, so they would be attracted to one another while rejecting advances from other, even closely-related, species.… Read full story

FDA Investigates Canine Heart Disease, Possibly Linked to Diet

The FDA is investigating the potential association between reports of heart disease (canine dilated cardiomyopathy [DCM]) and certain pet foods the animals consumed containing legumes or potatoes as main ingredients: https://go.usa.gov/xUKEf. As part of this investigation, we have been in contact with pet food manufacturers and the veterinary community to discuss these reports and will provide updates as more information becomes available.

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NIH Researchers Identify Sequence Leading to Release of Malaria Parasites From Red Blood Cells

Findings could inform the development of new antimalarial drugs.

What

The vacuole, a compartment inside human red blood cells in which malaria parasites reproduce and develop, takes on a distinctly spherical shape just minutes before its membrane ruptures, leading to the release of parasites into the bloodstream, according to researchers at the National Institutes of Health and other institutions.… Read full story