Discovery may lead to safer, more targeted drugs.
Antipsychotic drugs – which transformed mental health care following their chance discovery in the mid-20th Century – may finally be poised for a long-overdue makeover incorporating structure-based design. Scientists funded by the National Institutes of Health have achieved a landmark of psychiatric neuropharmacology: deciphering the molecular structure of a widely prescribed antipsychotic docked in its key receptor.… Read full story